Medication Dispensing
& Adherence System
Real-time clinical response data, wherever the patient is.
Non-adherence is the single most preventable cause of treatment failure, responsible for billions in avoidable healthcare costs and countless adverse outcomes. Dosage Adherence combines AppMed™; exclusive North American distribution of the Thess® electronic medication dispensing system with a bidirectional clinical feedback loop, closing the gap between prescribing and actual medication intake.
The Adherence Gap
$20M+
annual in cost-related non-adherence
- Real-time medication intake tracking — dose-by-dose confirmation through connected dispensing, not self-report
- Complex long-term dosing schedules supported— tapering, titration, multi-drug regimens and variable-interval schedules handled automatically
- 4G mobile — works outside home without WiFi
— adherence data keeps flowing during travel, in care facilities, or in connectivity-poor regions
- Instant remote dose adjustment capability
— clinicians can modify regimens on the fly without a pharmacy visit or device swap
-Rebić et al., CMAJ (Nov 2024)
The Adherence Crisis
Non-Adherence Is
the Most Preventable
Treatment Failure
Most treatment failures are not failures of the medication, they are failures of delivery. Without objective adherence monitoring, clinicians cannot distinguish between non-response and non-compliance.
01
ADHD: Non-Adherence Drives Symptom Breakthrough
Inconsistent stimulant medication intake in ADHD directly causes academic, occupational, and social impairment, yet most clinicians have no way to confirm whether prescribed doses are being taken as directed between visits.
02
ADHD: Adherence Collapses Within Months
In real-world data, stimulant treatment persistence averages just 136 days in children and adolescents and 230 days in adults within a 12-month follow-up, with medication possession ratios below 0.7 across every age group and drug class.
03
The "Non-Response vs Non-Compliance" Diagnostic Trap
When a patient reports poor symptom control, clinicians have no objective way to tell whether the medication failed or the doses were never taken. The result: unnecessary dose escalation, switches to second- and third-line agents, added side-effect burden, and months of lost treatment time, all avoidable with verified intake data.
04
Real-World Consequences of Missed Doses in ADHD
Unmedicated ADHD is associated with measurably higher rates of academic failure, motor vehicle accidents, substance use disorders, and workplace underperformance. Each missed dose is a missed day of executive function, and for stimulants specifically, there is no residual effect: protection ends the day the dose stops.
The Adherence Crisis
North America's Most Advanced
Electronic Dispensing System
AppMed™ is the exclusive North American distributor of the Thess® Corporate electronic medication dispensing system — a clinical-grade device that tracks medication intake in real time, supports complex dosing schedules, and operates on 4G mobile networks without WiFi or Bluetooth.
The bidirectional feedback loop between the Thess® device and AppMed’s clinical dashboard enables clinicians to identify non-adherence, alert patients selectively, and adjust prescriptions remotely — without requiring an in-person visit.
- Tracks medication intake in real time — dose-by-dose, with timestamp
- Supports complex long-term dosing schedules including multi-medication regimens
- 4G mobile connectivity — fully functional outside the home without WiFi or Bluetooth
- Tamper-proof medication containers with unforgeable drug identification
- Prevents medication counterfeiting through identity-secured packaging
- Selectively alerts non-adherent patients through the bidirectional feedback loop
- Monitors and flags adverse events reported by the patient
- Enables remote, instant dose adjustment by the prescribing clinician
Platform Capabilities
What Dosage Adherence Delivers
Six clinical capabilities that move ADHD medication management from population averages to individual precision.
Real-Time Dose Tracking
Every dispensed dose is recorded with a precise timestamp, providing clinicians with an objective, chronological adherence log that replaces patient recall entirely.
Selective Non-Adherence Alerts
The system identifies and alerts only non-adherent patients, preventing alert fatigue for compliant patients while ensuring clinicians are notified immediately when intervention is warranted.
Remote Instant Dose Adjustment
Clinicians can adjust the patient’s dispensing schedule remotely and instantly through AppMed’s clinical dashboard, without requiring an in-person visit or pharmacy visit.
4G Mobile — Works Anywhere
The Thess® device operates on 4G mobile networks, fully functional outside the home without WiFi or Bluetooth. Patients are monitored regardless of location.
Tamper-Proof Medication Security
Unforgeable drug identification on medication containers ensures authenticity, prevents counterfeiting, and provides a traceable medication chain of custody from pharmacy to patient.
Bidirectional Feedback Loop
A closed-loop system between patient device and clinical dashboard, alerting clinicians to missed doses and adverse events while enabling remote protocol adjustment in real time.
125k death
50%
Of patients with chronic conditions are non-adherent to their prescribed medication, the most common cause of preventable clinical deterioration
$13.5 : $1
Benefit-to-cost ratio of medication adherence in hypertension treatment, every $1 invested in adherence returns $13.50 in avoided healthcare costs
Part of a Connected Platform
Three Solutions, One Ecosystem
Dosage Optimisation works in concert with Dosage Monitoring and Dosage Adherence, creating a closed loop between modelled predictions and real-world clinical outcomes.
Solution - 01
Dosage Optimization
Model-informed Precision Dosing
Individualize dosing using validated pharmacokinetic and pharmacodynamic models, enabling safer titration for medications with narrow therapeutic windows.
Solution - 02
Dosage Monitoring
Remote Therapeutic Drug Monitoring and Clinical Assessment
Track treatment response continuously with patient-reported outcomes, therapeutic drug monitoring, microsampling biomarkers, and connected physiological devices.
Solution - 03
Dosage Adherence
Medication Dispensing System
Monitor adherence via connected MDS devices, enable remote dose adjustments, and intervene early before unplanned visits become necessary.
Get Started
See Dosage Optimisation
In Your Practice
Request a clinical demonstration of the PK modelling tool, tailored to your patient population and therapeutic area. See prescription simulation live, before a single dose is prescribed.
ADHD specialists · Pharmacologists · Clinical pharmacists · 24h response