Remote Therapeutic
Drug Monitoring

AppMed™ Platform · Solution 2 of 3

Real-time clinical response data, wherever the patient is.

Dosage Monitoring integrates three objective data streams, validated digital clinical questionnaires, remote therapeutic drug monitoring (TDM) via microsampling, and connected physiological devices, into a unified, real-time clinical dashboard. Clinical decisions backed by data, not guesswork.

Three Real-Time Data Streams

Digital Clinical Questionnaires — Validated PROs — patient, caregiver, and clinician inputs

Remote Therapeutic Drug Monitoring — At-home microsampling · ISO 15189 accredited lab

Connected Physiological Devices — Smart scales · BP monitors · Heart rate trackers

The Monitoring Gap

Clinical Decisions Made
Without Real Data

The clinical response to medication happens between appointments, yet most clinicians rely entirely on subjective patient recall during brief, scheduled visits to make treatment decisions.

01

No Objective Data Between Visits

Treatment response, side effects, and clinical deterioration all occur between appointments, but without continuous monitoring, clinicians see only a single, unrepresentative data point at each visit.

02

TDM Requires a Clinic Visit, So It Rarely Happens

Therapeutic drug monitoring requires venous blood draw at a clinic, a barrier that means most patients on narrow-therapeutic-window medications are never objectively monitored between prescriptions.

03

Questionnaires Are Paper-Based and Fragmented

Clinical PRO instruments are administered inconsistently, scored manually, and stored outside the clinical record, preventing longitudinal analysis and comparison against treatment changes.

04

Physiological Data Stays on the Device

Patients using connected health devices (scales, BP monitors) generate valuable data, but it lives in disconnected consumer apps, never reaching the clinician’s dashboard or the clinical record.

How Dosage Optimisation Works

One Unified Dashboard.
Three Objective Data Sources.

Dosage Monitoring integrates three independent, objective data streams into a single clinical view, replacing fragmented, subjective recall with continuous, structured clinical evidence.

Stream 01 · Digital PROs

Validated
Clinical Assessment

Validated, condition-specific digital questionnaires are administered directly on the patient’s device, integrating patient responses alongside caregiver, teacher, or coach inputs for a multi-perspective clinical picture.

Validated PRO instruments configured by therapeutic area (ADHD, pain, mental health)
Multi-contributor inputs: patient, caregiver, teacher, clinician
Time-series visualization of questionnaire results against dosing events
Automated triggering of additional assessments based on score thresholds

Patients collect blood capillary samples at home using a simple fingerprick microsampling device, samples are mailed via prepaid Canada Post expedited service and analyzed at a certified laboratory. Results are automatically integrated into AppMed™.

Minimally invasive home fingerprick collection — no clinic visit required
Analysis at an ISO 15189 and LSPQ accredited centralized laboratory
Results legally recognized for diagnostic and clinical decision-making purposes
Results automatically populated into the AppMed™ clinical dashboard

Coming soon

Stream 02 · Remote TDM

At-Home
Drug Level Monitoring

Stream 03 · Connected Devices

Real-Time
Physiological Monitoring

Connected wearable and sensor-based devices, including smart scales, pulse oximeters, and blood pressure monitors, transmit physiological data continuously to AppMed™, where it is integrated into the unified clinical dashboard alongside PROs and TDM results.

Remote TDM — How It Works

Laboratory Validation Required Before Availability

Lab-Grade Biomarker
Data, From Home

Remote therapeutic drug monitoring removes the single biggest barrier to objective pharmacological oversight, the requirement for a clinic visit. AppMed™’s microsampling workflow delivers lab-grade results directly into the clinical record.

Kit Dispatched to Patient

A microsampling kit containing a fingerprick device and collection card is mailed to the patient’s home.

Patient Self-Collects at Home

The patient performs a minimally invasive fingerprick and collects a small capillary blood sample, no special training required.

Sample Mailed to Laboratory

The sample card is mailed via prepaid Canada Post expedited service to the centralized analytical laboratory.

Analysis at Accredited Lab

The laboratory, holding ISO 15189 and LSPQ accreditation, analyzes the sample with clinical diagnostic accuracy.

Patient Self-Collects at Home

Biomarker results are automatically imported into the AppMed™ dashboard, overlaid on the PK model curve from Dosage Optimisation for direct comparison.

Laboratory Accreditation

ISO 15189

International standard for medical laboratory quality and competence. Ensures diagnostic-grade accuracy and reliability.

LSPQ Accredited

Laboratoire de santé publique du Québec accreditation, enabling legally recognized diagnostic results in medical contexts.

Diagnostic-Grade Results

Results meet the highest standards for clinical decision-making, legally recognized for use by healthcare professionals.

Canada Post Expedited

Prepaid expedited shipping ensures fast, reliable sample transit from patient home to accredited laboratory.

Integration with Dosage Optimisation

**Predicted vs. Actual — In One View**

Divergence between predicted and actual concentrations reveals critical clinical information: the patient may be a high or low metabolizer, or may not be responding as expected to the prescribed agent.

Blue PK curve = model-predicted plasma concentration over time
Red circles = actual measured TDM results from at-home microsampling
Divergence flags metabolic outliers and non-responders automatically

Part of a Connected Platform

Three Solutions, One Ecosystem

Dosage Optimisation works in concert with Dosage Monitoring and Dosage Adherence, creating a closed loop between modelled predictions and real-world clinical outcomes.

Solution - 01

Dosage Optimization

Model-informed Precision Dosing

Individualize dosing using validated pharmacokinetic and pharmacodynamic models, enabling safer titration for medications with narrow therapeutic windows.

Solution - 02

Dosage Monitoring